Cystic Fibrosis (CF), the most common life shortening autosomal recessive disease of Caucasian populations, is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene encoding a chloride (Cl-) channel expressed at the apical membrane of epithelial cells, a major regulator of salt and water transport in epithelia [1]. This evidence concerns the gene CFTR and autosomal recessive disease.