In contrast, among naive CD4+ T cells, % CD38- HLADR+ differed between groups at weeks 8 (p = 0.011), 12 (0.001), with Other IRIS having a lower % than No IRIS at these times (p = 0.004 and p < 0.001, respectively), as well as lower values than TB IRIS at week 12 (p = 0.034) (Additional file 5: Figure S4G). Here, CD38 is linked to tuberculosis.