Given that CD38+ HLADR+ CD8+ T cells are transiently expanded and that naive CD8+ T cells are significantly more numerous than other maturation subpopulations in the TB IRIS group, we calculated the absolute counts of CD38+ HLADR+ naive, CM and EM CD8+ T cells to determine whether an expansion of activated cells actually occurred among naive CD8+ T cells. The gene discussed is CD8A; the disease is tuberculosis.