These data suggest that E2A-PBX1 fusion transcripts caused by t(1;19)(q23;p13) may be a common somatic genetic change of importance in solid tumors and E2A-PBX1 may be a novel target for prognosis and therapy in adenocarcinoma in situ (AIS)[19]. This evidence concerns the gene PBX1 and adenocarcinoma in situ.