The parameters adversely affecting survival in all cases were high histologic grade(p < 0.01), tumor recurrence (p < 0.01), decreased Cygb expression(p < 0.01), increased PI3K expression(p < 0.01), increased p-Akt expression (p < 0.01) and increased VEGF expression (p = 0.023) (Table 3). Here, AKT1 is linked to neoplasm.