SNAP25 and schizophrenia: In our previous studies, the mutant mouse strains, αCaMKII HKO, Shn-2 KO, and SNAP-25 KI mice, exhibited severe impairments in working memory and increased locomotor activity, which are abnormal behaviors related to schizophrenia, and displayed the “immature dentate gyrus (iDG)” phenotype, in which DG granule cells fail to mature [35-38].