Other mutant mice with targeted point mutations in Grin1 show increased locomotor activity [26-28], reduced anxiety-like behaviors [27], abnormal social behaviors [29,30], deficits in spatial working memory [31], and decreased PPI [29], indicating that altered functions in Grin1 cause behavioral phenotypes related to schizophrenia, bipolar disorder, and ADHD. This evidence concerns the gene GRIN1 and attention deficit-hyperactivity disorder.