Perinuclear localization of RIG1 has been shown to inhibit expression or activation of signaling molecules such as HER2, RAS, PI3K/AKT, mTOR, and type I transglutaminase that are involved in the regulation of cell growth, apoptosis, tumor invasion, and cell differentiation [11-13,24,50]. The gene discussed is ERBB2; the disease is neoplasm.