Based on the composition of genes upregulated after the infection it is also clear that the response was a coordinated action of epithelial cells (induction of MMP7, LYG2, IL-8), T-lymphocytes (IL-1β, IL-17, IL-22, IFNγ), macrophages and heterophils (IRG1, SAA, ExFABP, TRAP6, MRP126, iNOS, AVD, AH221, IFIT5) and B-lymphocytes (IgG, IgA). The gene discussed is IL22; the disease is infection.