MTOR and heart failure: Indeed, markers of ER stress are also upregulated in hypertrophied and failing heart after aortic constriction.11 We now report that in hearts from a cohort of 11 nondiabetic patients with idiopathic dilated cardiomyopathy and heart failure, mechanical unloading with an LVAD reduces intracardiac G6P levels and decreases mTOR activation and protein levels of ER stress markers.