In summary, polysaccharides can increase the cytotoxic activity of macrophages against tumor cells and microorganisms, activate phagocytic activity, increase reactive oxygen species and NO production, and enhance secretion of cytokines and chemokines, such as TNF-α, IL-1, IL-6, IL-8, IL-12, and IFN-γ. Here, IL6 is linked to neoplasm.