ACHE and early-onset autosomal dominant Alzheimer disease: It is known that members of the genus Aspergillus can combine polyketide and terpene precursors to produce meroterpenoids, some of whom having important relevance to human health; this is the case of territrem B, produced by A. terreus, a potent irreversible inhibitor of acetyl cholinesterase (AChE) and a candidate for drug development for treating Alzheimer’s disease [204].