Taken together, dialysate containing high glucose induced massive aggregation of peritoneal M2, which, in turn, produced an amount of effector molecules leading to peritoneal fibrosis, which could be suppressed by LC via depletion of M2, and the influence of M2 on peritoneal fibrosis might associate with its effector molecule via TGF-β/Smad signaling pathway. The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.