Anti-ICAM-1 antibodies were purified by microaffinity chromatography from serum from six SSc patients with high reactivity to ICAM-1, and binding of purified IgG to recombinant ICAM-1 in the purified preparations was reaffirmed by anti-ICAM-1 ELISA (data not shown). This evidence concerns the gene ICAM1 and systemic sclerosis.