We observed two tSNPs in RTEL1 gene to be associated with the risk of glioma by recessive model (rs6010620, OR, 2.09; 95% CI, 1.39-3.13; P = 0.0004, and rs2297440, OR, 2.02; 95% CI, 1.35-3.04; P = 0.0007). This evidence concerns the gene RTEL1 and central nervous system cancer.