In addition, when 1,25(OH)2D3 is given prior to NMU, tumor incidence is prevented or reduced.1 1,25(OH)2D3 also reduces the incidence and severity of prostate neoplasia in a mouse model (Ndx 3.1; Pten mutant mouse), and 1,25(OH)2D3 has tumor inhibitory activity in a mouse model of colorectal adenoma (Apcmin). The gene discussed is PTEN; the disease is neoplasm.