It provides some evidence that human ficolins, such as L-ficolin and M-ficolin, can be used as available formulation in vaccine to defend the human infected Plasmodium. However, we need do more work to understand the anti-malaria mechanism of ficolin-A in mice, and whether excessive expression of ficolins in vivo might elicit other autoimmunity damages need further investigation. Here, FCN1 is linked to malaria.