ITPR1 and cancer: Our observation is fully in line with a previous report showing that OCI-LY-1 displayed high levels of Bcl-2/Bax complex formation, which was not the case for SU-DHL-4.12 Hence, it seems that dependent on the apoptotic escape route cells may be addicted to high levels of Bcl-2 either to suppress aberrant IP3R activity (like in the case of IP3R2-expressing cancer cells, e.g., SU-DHL-4) or to suppress aberrant Bax activity (like in the case of IP3R3-expressing cancer cells, e.g., OCI-LY-1).