TSHR and Graves disease: Graves' disease, one of the thyroid autoimmune diseases, is characterized – in its typical form – by hyperthyroidism with laboratory results of decreased thyrotropin (TSH) level, increased free thyroxine (FT4) and/or free triiodothyronine (FT3) levels, detectable TSH receptor (TSHR) stimulating antibodies (TSHRAb), usually positive thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) [12].