Accordingly, the components of the HPA axis provides numerous genes that might be associated with risk for MDD, including, but not limited to, a key component of the glucocorticoid receptor complex, FK506-binding protein 5 (FKBP5), corticotropin-releasing hormone receptor 1 (CRHR1) and corticotropin-releasing hormone-binding protein (CRHBP) [1]. This evidence concerns the gene CRHR1 and major depressive disorder.