At nine weeks of age she was investigated for progressive cholestasis (serum bilirubin 534 μmol/L (0-15 μmol/L), gamma glutamyl transferase (GGT) 131 IU/L (25-70 IU/L), alanine transaminase (ALT) 1769 IU/L (5-45 IU/L), aspartate transaminase (AST) 2078 IU/L (20-60 IU/L)) and persistent hypoglycaemia. This evidence concerns the gene GPT and cholestasis.