The CD4+ and CD8+ recovery of co-infected group 2 was impaired by the co-infection of HCV despite the presence of HAART (CD4+: 148 Vs 343; P < 0.003 and CD8+: 1104 Vs 1259; P < 0.004) at the baseline and the last (fourth year). This evidence concerns the gene CD4 and coinfection.