To address whether Fbxw7 propellor tip mutant protein could promote the development of intestinal polyposis initiated by Apc mutations, R482Q mice were bred with two Apc mutants, Min26 and 1322T.27 R482Q/+; Apc compound mutant (test) and Fbxw7 wild-type; Apc mutant (control) mice were aged until test mice were symptomatic. The gene discussed is APC; the disease is gastrointestinal polyp.