KLF5 and intestinal neoplasm: KLF5 is a zinc finger family transcription factor that plays a role in multiple cellular processes, including cell cycle regulation, proliferation and angiogenesis.33 It is primarily expressed in proliferative regions of the intestinal epithelium,34 and most data suggest that it promotes G1–S phase transition.34, 35 We found no significant changes in proliferation in morphologically normal tissue from R482Q mutant mice but it has been shown31, 36 that Klf5+/− mice have a greatly reduced intestinal tumour load.