Since one given miRNA could target multiple mRNAs of different genes and a given target may be regulated by multiple miRNAs [59], whether these miRNAs involve in the dysregulation of the hormone receptors (AR, FSHR and ER) and intra-ovarian regulators of ovarian follicle growth and function in PCOS is unknown. This evidence concerns the gene ESR1 and polycystic ovary syndrome.