ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: For this approach to be successful further work needs to be performed in a number of areas including: (a) the development of more clinical grade self-renewal pathway modulators; (b) the development of sensitive and robust tests to monitor MRD (e.g. quantitative RT-PCR for BCR-ABL in CML); and (c) the development of assays to allow measurement of the rare LSC population size and functionality.