Most subsequent studies, performed in both wild-type BALB/c mice and cancer-prone BALB-neuT transgenic mice, confirmed the existence of this vaccine’s unique ability to trigger protective immunity toward rat HER2-positive tumors (Rovero et al., 2000; Curcio et al., 2003; Quaglino et al., 2004; Rolla et al., 2008). Here, ERBB2 is linked to cancer.