This lack of equilibrium leads to the systemic secretion of various factors, such as TNF-α, IL-6, insulin, insulin-like growth factor-1 (IGF-1), adiponectin, and leptin, which play an important role in carcinogenesis including CRC (Harvey et al., 2012; Vucenik and Stains, 2012). Here, IGF1 is linked to colorectal carcinoma.