Several mechanisms by which probiotics may suppress CRC development have been suggested, including induction of the adaptive immune response through increased production of inflammatory cytokines, such as TNF-α and IL-6; further modulating downstream detoxification pathways (CYPs, GSTs, COX-2) and reducing the uptake of carcinogenic compounds (Rafter, 2004). This evidence concerns the gene HPGDS and colorectal carcinoma.