The similarity of the gene profiles of AD and 3D cells in five-day RPM treated samples is also notable because the expression of only two genes (IFIT1, CTGF) differs by a factor of two, while regarding the seven-day RPM treated samples, 3 genes (NFKBIZ, NR4A2, FOS) in 3D cells are more than three-fold upregulated as compared to the corresponding AD cells, and the expression of another 30 genes including MMP2, MMP9, and MMP10 as well as FOSL, PRDX3 and TNRSF25 in the 3D and AD cells differs by a factor of two (Table S2). The gene discussed is CCN2; the disease is Alzheimer disease.