Recent studies indicate that DDRGK1 interacts with a protein complex containing UFL1 (UFM1-specific ligase 1), the putative tumor suppressor LZAP/C53 and UFM1 (ubiquitin fold modifier 1), and both UFL1 and LZAP/C53 have a regulatory role in the NF-κB pathway [8], [9], [10]. This evidence concerns the gene CDK5RAP3 and neoplasm.