Intriguingly, since hypoxia is suggested to promote development of CR disease in prostate cancer, STAT5; as was found to be significantly activated already in ADL xenografts in this study, may represent a key hypoxia-induced factor involved in subsequent reactivation of angiogenesis-related kinase signaling, which consequently stimulates renewed, CR tumor growth. The gene discussed is STAT5A; the disease is Familial prostate cancer.