CBS and hyperhomocysteinemia: Mild hyperhomocysteinemia in heterozygous cystathionine-β-synthase (Cbs) deficient mice was accompanied by cardiomyocyte hypertrophy and myocardial collagen accumulation [10], which is consistent with similar observations in normotensive and hypertensive rats with diet-induced hyperhomocysteinemia [8], [11].