If we restrict the data to those of melanoma cells, it seems possible to distinguish two distinct groups: firstly, the lines (A375, Hs294T and MeWo) with high levels of expression of major drug targets TS, DHFR, and AICART GARFT and on the other hand, those lines (HT144) with low levels of expression of said enzymes. This evidence concerns the gene DHFR and melanoma.