Previously, we reported that TPA addition to MCF-7 breast cancer cells cultured under estrogen-free serum starved conditions resulted in the recruitment of MSK1 to the TFF1 UPE, along with increased H3S10ph (but not H3S28ph) and H3 acetylation (H3K9acK14ac) levels [27]. This evidence concerns the gene RPS6KA5 and breast carcinoma.