MET and hepatocellular carcinoma: In this study, we show that a novel ADC (MetFab-DOX) consisting of doxorubicin conjugated to a human anti-c-Met Fab can target to c-Met expression HCC cells and still preserve the cytotoxicity effect of DOX after the conjugation, and it only specifically bound to HCC cells that expressed c-Met and had cytotoxic effect on those cells, but not on the cells that did not express c-Met.