Sun et al. have recently shown that the antitumor agent curcumin which has been shown to inhibit the proliferation and induce apoptosis of a variety of tumor types may mediate the death of pancreatic cancer cells through its upregulation of the expression of miR-22 and the subsequent targeting of the transcription factor SP1 and estrogen receptor 1 [34]. This evidence concerns the gene ESR1 and neoplasm.