KCNJ10 and Mental deterioration: Relevant clues can be drawn from Kir4.1 knock-out mice, which display seizure, hearing loss, altered K+ transport in hippocampus, impaired glutamate uptake by astrocytes, motor impairment due to hypomyelination, but not clear signs of cognitive decline as in affected patients bearing Kir4.1 mutations ( Djukic et al., 2007).