Some individuals bearing Kv1.1 mutations also experience epilepsy and cognitive decline which may result from altered glutamate neurotransmission at the hippocampal CA3 region, as a consequence of impaired Kv1.4–1.1/Kvβ1.1 channel inactivation ( Geiger and Jonas, 2000; Imbrici et al., 2006). The gene discussed is KCNA1; the disease is epilepsy.