Zhang et al. (2010a) performed a detailed association analysis on 2,756 SNP markers in the chromosome 8q24 region of 3,512 individuals from 737 families. Their results showed suggestive evidence of association of BPD with loci near KCNQ3 gene, encoding the voltage-gated potassium channel Kv7.3. Kiselycznyk et al. (2012), instead, excluded the involvement of Kir4.2 in anxiety or depression by analyzing the neurological functions of KCNJ15 knock-out mice on a battery of behaviors including those related to anxiety and depression, and on plasticity-related learning tasks. This evidence concerns the gene KCNQ3 and major depressive disorder.