Studies investigating the combined effect of GST-deletions, XRCC1 (Arg194Trp and Arg399Gln), XRCC3 (Thr241Met), TP53 (Arg72Pro), and CCND1 (A870G) will be very important for further evaluate the role of these polymorphism in different cancers. This evidence concerns the gene CCND1 and cancer.