Recruitment of both intracellular and extracellular sources of Ca2+ after activation of PAC1 receptors has already been reported in several models including the rat acinar cell line AR42J (Barnhart et al., 1997), the human neuroblastoma cell line NB-OK-1 (Delporte et al., 1993), and primary cultures of rat cortical neurons (Grimaldi and Cavallaro, 1999). Here, ADCYAP1R1 is linked to neuroblastoma.