SELPLG and neoplasm: In vitro analysis of hypoxia in tumor cell lines showed that resveratrol (Zhang et al., 2005; Park et al., 2007) and two isoforms of conjugated linoleic acid (CLA) c9,t11- and t10,c12-CLA (Yamasaki et al., 2012) can promote HIF-1α protein degradation; suggesting that the hypoxia related inflammatory response in WAT is nutrient sensitive.