PANX1 and Stroke: Panx1 channels also interact with other proteins, such as the purinergic receptor P2X7 and possibly inflammasome components involved in the innate immune response and associated secondary cell death (Pelegrin and Surprenant, 2006; Locovei et al., 2007; Silverman et al., 2009), thus responsible for amplification of the primary lesion in CNS trauma, stroke and epilepsy (Bergfeld and Forrester, 1992; De Rivero Vaccari et al., 2009; Santiago et al., 2011).