Although in this study serum IL-1β levels were too low to be detected (Su et al., 2012), a role for IL-1β in post-stroke depressive symptoms has been confirmed in animal models in which the anhedonia elicited by middle cerebral artery occlusion was attenuated by intracerebrovascular injection of IL-1ra (Craft and DeVries, 2006). The gene discussed is IL1B; the disease is Stroke.