Nevertheless, a prospective examination of cytokine changes during post-stroke recovery revealed that among those patients that expressed depressive symptoms one year after stroke, serum concentrations of IL-6, IL-10, TNF-α, and IFN-γ were concomitantly increased, supporting the supposition that these key cytokines might contribute to, or be an index of, post-stroke depressive symptoms (Su et al., 2012). This evidence concerns the gene TNF and stroke disorder.