Moreover, in mice with a genetic deletion of MIF (Inácio et al., 2011b) or in which MIF was diminished following housing in an enriched environment (Inácio et al., 2011c), smaller infarct size and a better functional outcome were apparent after transient focal ischemia, pointing to a role for MIF in neuronal death and in functional deficits elicited by stroke. This evidence concerns the gene MIF and Stroke.