Likewise, pre-treatment with the IL-1β antagonist IL-1ra reversed the impaired neurogenesis elicited by in vitro IL-1β or by stressors (Koo and Duman, 2008) as well as the down-regulated hippocampal BDNF and cognitive impairments elicited by social isolation in mice (Barrientos et al., 2003). Here, IL1B is linked to Cognitive impairment.