In addition, inducing glucopenia around the VMH using 2-deoxyglucose (a non-metabolizable glucose analog), resulted in an immediate increase in plasma glucose in association with a marked elevation of glucagon, epinephrine, and norepinephrine, suggesting that neurons in the VMH play a critical role in triggering the release of counterregulatory hormones important for defending against hypoglycemia (Borg et al., 1995). This evidence concerns the gene GCG and Hypoglycemia.