Upon SB203580 injection, WT mice exhibited reduced RIP2 expression and phosphorylation, and P38 phosphorylation in total peritoneal cells and serum and peritoneal IL-1β, IL-10, and C5a levels during sepsis, whereas these were unaffected in Nod2−/− mice (Fig. 6B and C). Here, C5 is linked to Sepsis.