NOD2 and Sepsis: Real-time PCR analysis revealed that NOD2 expression in F4/80−Ly-6G+ neutrophils was constitutive and sustained during sepsis, whereas F4/80+Ly-6G− macrophages showed low expression levels of NOD2 before, and 4 and 12 h after CLP, but highly expressed NOD2 24 h after CLP, which was consistent with expression pattern of NOD2 in blotting assay (S3A and B).