Furthermore, considering the CD55 expression levels on neutrophils from WT, Il-1r−/−, Il-10−/−, and Nod2−/− mice with CLP, it is conceivable that NOD2-mediated IL-10 production suppresses CD55 expression on peritoneal neutrophils during sepsis in both IL-1β-dependent and IL-1β-independent manners. Here, IL1B is linked to Sepsis.