Therefore the feasibility of controlling hyperglycemia was attempted in the volunteers where the plasma levels of dermcidin were positively correlated with that of the plasma glucose levels, by the increase of hepatic insulin synthesis through the systemic stimulation of nitric oxide synthesis in human subjects with T1DM, similar to the alloxan induced insulin dependent diabetes mellitus in animal model, as reported before (7). The gene discussed is INS; the disease is diabetes mellitus.