However unlike the pancreatic cells in T1DM, the synthesis of insulin could be normalized by the hepatic synthesis of the hormone through the increased systemic NO level in both the alloxan induced diabetes mellitus in animal model (7) where the pancreatic β cells are reported to be completely destroyed or in the case of humans as presented above with T1DM where the β cells are reported to be destroyed (26). This evidence concerns the gene INS and diabetes mellitus.