The down regulation of hormone receptor numbers by the same hormone receptor interaction, usually called “homologous” receptor down regulation is known in the case of insulin for same, where the binding of one molecule of the ligand to its receptor is reported to cause decrease of the binding of a second molecule of insulin to its receptor, generally known as the negative co operatively among the receptor which could be of physiologically important in the prevention of insulin induced hypoglycemia (27). The gene discussed is INS; the disease is Hypoglycemia.