By inserting the interleukin-24 (IL-24) into the oncolytic adenovirus (OncoAd), the resulting OncoAd-IL-24, here is ZD55-IL-24 (ZD55 is an OV from adenovirus, i.e. the OncoAd) has much higher anti-tumour effect than that of Ad-IL-24 (Ad is a replication deficient adenovirus) in vitro, also higher anti-tumor effect than that of ZD55 (OV) and no toxicity to normal cells as shown in Fig. 1A (15). Here, IL24 is linked to neoplasm.