The other example for the excellent anti-tumor effect of IL-24 is the combination of ZD55-IL-24 plus ZD55-TRAIL in which all the xenografted BEL 7404 hepatoma could be completely eradicated (Fig. 5A) since ZD55-IL-24 could up-regulate the expression of TRAIL (21) (Fig. 5C and ZD55-TRAIL could enhance the apoptotic effect of ZD55-IL-24 (21) as shown in Fig. 5B. Here, TNFSF10 is linked to neoplasm.