With the same IL-24 gene, Ad•DD3•E1A•(IL-24) or Ad•AFP•E1A•ΔE1B•(IL-24) could completely eliminate xenograft tumor, but the Ad•AFP•E1A•E1B(Δ55)•IL-24 could not (22), showing the importance of vector. The gene discussed is IL24; the disease is neoplasm.