DD3 (differential display code3), a prostrate specific promoter was constructed as oncolytic viral vector (Ad•DD3•E1A) to drive IL-24 and construct Ad•DD3•E1A•(IL-24) (Fig. 3A), which has the excellent anti-tumor effect and could completely eradicate the xenograft praste cancer (Fig. 3B) (20). Here, IL24 is linked to cancer.