GPX3 and thrombotic disease: Consistent with this role, functional transcription site of the GPx-3 gene showed that it is regulated by oxygen tension and redox state (73).Therefore, it is hypothesized that mutation(s) or polymorphism(s) in the plasma GPx-3 gene promoter may be responsible for the reduction in enzyme activity and predispose to a thrombotic disorder, thus constituting a genetic risk factor for thrombotic cerebrovascular disease.