IGHE and allergic disease: Anyway, present QME5 might be more valuable for lab research, or diagnosis for human IgE detection, however, high-affinity or affinity-maturated anti-IgE antibodies screened from E34 immunized mice in future might be a candidate targeting IgE/FcɛRIα complex and should have potential capacity of neutralizing soluble IgE against the receptor in vivo for preventing or treating IgE-mediated allergic diseases.