Caspase activation is thought to be an important mechanism for the apoptotic cell death program; however, our findings suggest that cell death induced by the combination treatment of celecoxib and TNF-α in human cervical cancer cells is caspase-independent as there was no significant increase in of caspase-3 activity though the cytosolic cytochrome c was elevated. The gene discussed is TNF; the disease is cervical carcinoma.