In his research, the onset of severe preeclampsia was significantly earlier in women with the G20210A prothrombin gene mutation (24.5 weeks vs. 30.1 weeks, P=0.046) and in women with the PAI-15G-5G genotype (25.7 weeks vs. 30.8 weeks, P=0.024), showing that these risk factors do not induce the pathomechanism but accelerate the course of preeclampsia (34). This evidence concerns the gene F2 and preeclampsia.