We didn’t find an increased incidence of adverse pregnancy outcomes in subjects with protein S deficiency, hyperhomocysteinemia, C677T or A1298C MTHFR homozygous mutation, G20210A Prothrombin homozygous mutation, G1691A factor V homozygous mutation, PAI-1 homozygous mutation. This evidence concerns the gene MTHFR and hyperhomocysteinemia.