For example, when we re-infected RIP-LCMV-NP mice with a heterologous virus (Pichinde Virus, PV) at week 4 after LCMV-infection, we observed a massive acceleration of T1D with similar kinetics as observed in RIP-LCMV-NP x RIP-CXCL10 mice (38). Here, CXCL10 is linked to type 1 diabetes mellitus.