POMC and major depressive disorder: In the present study, applying Maca-GO treatment to early-postmenopausal women, in addition to a significant increase in E2, lowered LH, T3, CT, ACTH and steady FSH and PRG levels, there was a highly significantly reduction in BMI and both frequency and intensity of menopausal symptoms such as hot flushes, profound perspiration (night sweating), as well as reduced depression, irritability, difficulty in falling asleep and other as demonstrated by the KMI and GMS, which may indicate similar effect as the one induced by the HRT treatment.